The vitamin D receptor (VDR) is a protein that is activated by vitamin D. It https://dataroomsearch.net/vdr-is-to-access-your-companys-valuable-assets-from-anywhere-on-the-web/ is interested in maintaining the mineral equilibrium in the body and causing growth and hair creation. It also treats adipose cells.
VDRs are expressed in the parathyroid glands, intestines, epithelial skin cells, and many the immune system cell types. They are thought to regulate the intestinal absorption of calcium, and to mediate some of the effects of vitamin D upon bone protection. Also, they are thought to enjoy an important role in metabolic rate.
VDR can be found in a variety of damaged tissues, including epithelial cells, macrophages, neutrophils, and skin keratinocytes. However , they are most widely depicted in the kidneys and halloween bones.
The VDR is phosphorylated on serine residues by many protein kinases. These kinases include PKA and PKC. The effect of these kinases about VDR is ligand reliant. Specifically, the phosphorylation of Ser51 simply by PKC reduced VDR nuclear localization. Likewise, phosphorylation of Ser182 by PKA reduced RXR heterodimerization.
Studies have shown that VDRs can be found in a subsection, subdivision, subgroup, subcategory, subclass of glial cells, particularly in oligodendrocytes in white matter. Although VDR immunoreactivity has been discovered in a number of glial cell lines, no information has been presented that the existence of VDR in glia is a cause for increased likelihood of tumorigenesis.
Additionally , VDR appears to be present in a subset of neurons. Actually nuclear discoloration has been demonstrated in real human cortex and glial cell-lines.
A large 220-kDa protein can be found in human major glioblastoma cells. In contrast, a little recombinant VDR-like protein was produced.